Backed by Science

The Metavo ability to manage blood sugar, boost metabolism, and improve health is no small feat.* Our scientists have spent the better part of a decade researching and discovering a new bioactive ingredient found only in a unique subset of avocados – Avocatin-B (AvoB™). 

After we eat, the amount of glucose in our blood rises

Insulin is released to bring blood sugar levels back down to "normal" levels

When the body starts to ignore the insulin message (insulin resistance), blood sugar levels rise and can lead to weight gain, hypertension, prediabetes and type 2 diabetes.

Metavo works to support normal blood sugar levels and maintain healthy metabolism.

Learn more about Metavo for diabetics

If you are interested in learning more about the technical science behind Metavo, check out our clinical studies and published research.

SP Nutraceuticals report on Metavo

This report illuminates the science behind the powerful bioactive compound AvoB, harnessed from a unique subset of avocados, and chromium, an essential mineral that improves insulin action in the body. This report looks at chronic conditions like diabetes and metabolic syndrome and how the health benefits of avocados, AvoB, and chromium work together to restore insulin sensitivity and blood glucose levels.

A clinical trial published in Molecular Nutrition & Food Research, 2019

In this 8-week trial, mice were fed high-fat diets and given AvoB, which led to improved glucose tolerance, glucose utilization, and insulin sensitivity. Afterward, a randomized, double-blind, placebo-controlled clinical trial in healthy human participants confirmed the findings and AvoB’s nutritional and clinical importance.

A study published in Scientific Reports, 2020

This study establishes the promising pharmacokinetic and biodistribution of AvoB in biological systems. Pharmacokinetics is the study of the bodily absorption, distribution, metabolism, and excretions of drugs and substances of interest. Biodistribution is a tracking method where compounds of interest travel in a human or animal subject. 

A clinical trial published in Clinical Obesity, 2019

This trial looked at the role of chromium as a weight loss agent and established that chromium supplementation was associated with some improvements in body composition in subjects with obesity. However, the clinical relevance of chromium as a weight loss aid remains uncertain. 

A clinical trial published in the Journal of Clinical Pharmacy and Therapeutics, 2014

This trial established in randomized controlled trials that chromium mono- and combined supplementation significantly improved glycaemic control. The evidence suggests favourable effects of chromium supplementation on glycaemic control in patients with diabetes.

Our founder, Dr. Paul Spagnuolo speaks with Allison Tannis, on the Natural Health Influencer Podcast. 

The Natural Health Influencer podcast is hosted by nutrition expert and author Allison Tannis of @deliciouslygeeky. She speaks with Dr. Spagnuolo who gives a detailed breakdown of what insulin resistance is and how it affects our health before explaining the research that he has been doing on avocados for the past 10 years. 

We stand behind our product.