We’ve Got Awesome Down to a Science

Avocatin-B—The Breakthrough Scientific Discovery That Started the Metabolism Movement

Boost Metabolism | Manage Blood Sugar | Improve Health

The Best of Mother Nature +Science

It’s not often you get the best of both worlds: Mother Nature and Science. But with Metavo’s key ingredient AvoB™, that is what you get.

Because AvoB was a surprise discovery in a lab, and is backed by clinical research that show its efficacy. Yet, this key ingredient is also a powerful naturally derived and naturally acting agent. Science, meet Mother Nature.

The Best of Mother Nature +Science

It’s not often you get the best of both worlds: Mother Nature and Science. But with Metavo’s key ingredient AvoB™, that is what you get.

Because AvoB was a surprise discovery in a lab, and is backed by clinical research that show its efficacy. Yet, this key ingredient is also a powerful naturally derived and naturally acting agent. Science, meet Mother Nature.

A Decade of Scientific Research

Our scientists, including our lead scientist Dr. Paul Spagnuolo, have spent the better part of a decade researching and discovering AvoB, which Dr. Paul found only in a unique subset of avocados—its longform being Avocatin-B (AvoB™). And now, AvoB is found exclusively in Metavo as the driving natural bio-active ingredient—bioactive meaning, a type of chemical found in small amounts in plants and certain foods like fruits, vegetables, and nuts.

YES—I WANT TO ACTIVATE MY METABOLISM!

A Decade of Scientific Research

Our scientists, including our lead scientist Dr. Paul Spagnuolo, have spent the better part of a decade researching and discovering AvoB, which Dr. Paul found only in a unique subset of avocados—its longform being Avocatin-B (AvoB™). And now, AvoB is found exclusively in Metavo as the driving natural bio-active ingredient—bioactive meaning, a type of chemical found in small amounts in plants and certain foods like fruits, vegetables, and nuts.

YES—I WANT TO ACTIVATE MY METABOLISM!

Understanding How the Body Works

The First Step in Taking Charge of Your Health

Experience the Metavo Difference in 30 Days!

ACTIVATE
Days 1-4. Starts to activate a healthy metabolism and blood sugar.

OPTIMIZE
Days 15-30. Optimizes an active metabolism, and balances blood sugars. You should experience reduced sugar cravings and more energy.

MAINTAIN
Day 30 onward. You’ve been activated! Your metabolism is working properly.

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Science Doesn’t Lie

AvoB has over a decade of supporting scientific research. In fact, avocado alone, as it pertains to great health, has OVER 100 studies that show its efficacy.
But don’t just take our word for it. Check out the science for yourself.

Dr. Spagnuolo’s clinical safety research on humans demonstrates AvoB™ is safe even in upper-limit dosages. Additionally, his university-led pre-clinical trial quantifies the impact of AvoB™.

15%

IMPROVE GLUCOSE TOLERANCE

25%

INSULIN RESISTANCE UP BY

20%

LOWER BODY WEIGHT BY

After we eat, the amount of glucose in our blood rises

Insulin is released to bring blood sugar levels back down to "normal" levels

When the body starts to ignore the insulin message (insulin resistance), blood sugar levels rise and can lead to weight gain, hypertension, prediabetes and type 2 diabetes.

Metavo works to support normal blood sugar levels and maintain healthy metabolism.

If you are interested in learning more about the technical science behind Metavo, check out our clinical studies and published research.

SP Nutraceuticals report on Metavo

This report illuminates the science behind the powerful bioactive compound AvoB, harnessed from a unique subset of avocados, and chromium, an essential mineral that improves insulin action in
the body. This report looks at chronic conditions like diabetes and metabolic syndrome and how the health benefits of avocados, AvoB, and chromium work together to restore insulin sensitivity and blood glucose levels.

A clinical trial published in Molecular Nutrition & Food Research, 2019

In this 8-week trial, mice were fed high-fat diets and given AvoB, which led to improved glucose tolerance, glucose utilization, and insulin sensitivity. Afterward, a randomized, double-blind, placebo-controlled clinical trial in healthy human participants confirmed the findings and AvoB’s nutritional and clinical importance.

A study published in Scientific Reports, 2020

This study establishes the promising
pharmacokinetic and biodistribution of AvoB in biological systems. Pharmacokinetics is the study of the bodily absorption, distribution, metabolism, and excretions of drugs and substances of interest. Biodistribution is a tracking method where compounds of interest travel in a human or animal subject.

A clinical trial published in Clinical Obesity, 2019

This trial looked at the role of chromium as a weight loss agent and established that chromium supplementation was associated with some improvements in body composition in subjects with
obesity. However, the clinical relevance of chromium as a weight loss aid remains uncertain.

A clinical trial published in the Journal of Clinical Pharmacy and Therapeutics, 2014

This trial established in randomized controlled trials that chromium mono- and combined supplementation significantly improved glycaemic control. The evidence suggests favourable effects of chromium supplementation on glycaemic control in patients with diabetes.

Our founder, Dr. Paul Spagnuolo speaks with Allison Tannis, on the Natural Health Influencer Podcast

The Natural Health Influencer podcast is hosted by nutrition expert and author Allison Tannis of @deliciouslygeeky. She speaks with Dr. Spagnuolo who gives a detailed breakdown of what insulin resistance is and how it affects our health before explaining the research that he has been doing on avocados for the past 10 years.

University-Led

Placebo-Controlled

Double-Blind

8 Weeks

Backed by Preclinical Studies

Non-GMO

Gluten Free

Vegan

No Added Sugar

Sulfite Free

No Artificial Flavours or Preservatives